TY - JOUR TI - Relative index of inequality and slope index of inequality: a structured regression framework for estimation AU - Moreno-Betancur, Margarita AU - Latouche, Aurélien AU - Menvielle, Gwenn AU - Kunst, Anton E. AU - Rey, Grégoire T2 - Epidemiology (Cambridge, Mass.) AB - BACKGROUND: The relative index of inequality and the slope index of inequality are the two major indices used in epidemiologic studies for the measurement of socioeconomic inequalities in health. Yet the current definitions of these indices are not adapted to their main purpose, which is to provide summary measures of the linear association between socioeconomic status and health in a way that enables valid between-population comparisons. The lack of appropriate definitions has dissuaded the application of suitable regression methods for estimating the slope index of inequality. METHODS: We suggest formally defining the relative and slope indices of inequality as so-called least false parameters, or more precisely, as the parameters that provide the best approximation of the relation between socioeconomic status and the health outcome by log-linear and linear models, respectively. From this standpoint, we establish a structured regression framework for inference on these indices. Guidelines for implementation of the methods, including R and SAS codes, are provided. RESULTS: The new definitions yield appropriate summary measures of the linear association across the entire socioeconomic scale, suitable for comparative studies in epidemiology. Our regression-based approach for estimation of the slope index of inequality contributes to an advancement of the current methodology, which mainly consists of a heuristic formula relying on restrictive assumptions. A study of the educational inequalities in all-cause and cause-specific mortality in France is used for illustration. CONCLUSION: The proposed definitions and methods should guide the use and estimation of these indices in future studies. DA - 2015/07// PY - 2015 DO - 10.1097/EDE.0000000000000311 DP - PubMed VL - 26 IS - 4 SP - 518 EP - 527 J2 - Epidemiology LA - eng SN - 1531-5487 ST - Relative index of inequality and slope index of inequality KW - Educational Status KW - Female KW - France KW - Health Status Disparities KW - Humans KW - Linear Models KW - Male KW - Mortality KW - Proportional Hazards Models KW - Regression Analysis KW - Social Class KW - Socioeconomic Factors KW - Statistics as Topic ER -