TY - JOUR TI - Emerging role of hepatocellular carcinoma among liver-related causes of deaths in HIV-infected patients: The French national Mortalité 2005 study AU - Salmon-Ceron, Dominique AU - Rosenthal, Eric AU - Lewden, Charlotte AU - Bouteloup, Vincent AU - May, Thierry AU - Burty, Christine AU - Bonnet, Fabrice AU - Costagliola, Dominique AU - Jougla, Eric AU - Semaille, Caroline AU - Morlat, Philippe AU - Cacoub, Patrice AU - Chêne, Geneviève AU - ANRS EN19 Mortalité Study Group and Mortavic T2 - Journal of hepatology AB - BACKGROUND/AIMS: Longer exposure to hepatitis C (HCV) or B virus (HBV) and the increased use of hepatitis treatment might have an impact on liver-related deaths in patients co-infected with the Human Immunodeficiency Virus (HIV). We describe the proportion of liver-related deaths among HIV-infected patients in 2005 compared with 2000. METHODS: In a nationwide survey (341 hospital departments involved in HIV management), all deaths of HIV-infected patients were prospectively reported. Deaths from either cirrhosis, hepatocellular carcinoma or fulminant hepatitis were defined as liver-related deaths. RESULTS: Of the 898 deaths reported in 2005, liver-related causes accounted for 15.4%; this is compared to 13.4% in 2000. Among liver-related deaths, hepatocellular carcinoma increased from 15% to 25% (p=0.04). Among hepatocellular carcinoma-related deaths: in 2000, 10% were HCV-infected; in 2005, 25% were HCV-infected (p=0.03). Half of the HCV-related deaths had been treated for HCV but 98% remained HCV-RNA positive at time of death. The proportion of HBV-related deaths remained stable between 2000 and 2005. CONCLUSIONS: Liver-related deaths, mainly liver cancers, have increased in HIV-infected patients in France despite wide access to HCV treatment. The stability of HBV-related deaths might be explained by the use of dually active antiretroviral drugs in co-infected patients. DA - 2009/04// PY - 2009 DO - 10.1016/j.jhep.2008.11.018 DP - NCBI PubMed VL - 50 IS - 4 SP - 736 EP - 745 J2 - J. Hepatol. LA - eng SN - 1600-0641 ST - Emerging role of hepatocellular carcinoma among liver-related causes of deaths in HIV-infected patients KW - Adult KW - Carcinoma, Hepatocellular KW - Female KW - France KW - HIV Infections KW - Hepatitis B KW - Hepatitis C KW - Heterosexuality KW - Homosexuality KW - Humans KW - Liver Cirrhosis, Alcoholic KW - Liver Neoplasms KW - Male KW - Middle Aged KW - Substance Abuse, Intravenous ER -