TY - JOUR TI - [Causes of death in HIV-infected French drug users, 1995-2000] AU - Lewden, Charlotte AU - Bonnet, Fabrice AU - Bevilacqua, Sibylle AU - Heripret, Laurence AU - May, Thierry AU - Morlat, Philippe AU - Jougla, Eric AU - Dabis, François AU - Chêne, Geneviève AU - Salmon, Dominique AU - Groupe d'Epidémiologie Clinique du SIDA en Aquitaine AU - Groupe "Mortalité 2000" T2 - Annales de médecine interne AB - Since the decline in mortality among HIV-infected persons after introduction of highly active antiretroviral therapy, concerns related to co-morbidities have increased as they may impair vital prognosis, particularly in intravenous (IV) drug users. We describe firstly the changes in the distribution of the causes of death between 1995 and 2000 among IV drug users in the "Aquitaine Cohort" based on hospital information system, and secondly the distribution of the causes of death among IV drug users in the French national survey "Mortalité 2000" specifically set up in 2000 for optimal exhaustiveness. The total number of deaths declined between 1995 and 2000 and 1/3 were IV drug users. Deceased IV drug users were younger than other deceased patients, had longer median time from diagnosis of HIV infection and higher median CD4 cell count. Poor socio-economic conditions were notified in 55%. Among IV drug users, the proportion of AIDS-related deaths was above 75% in 1995 and below 30% in 2000. In 2000, 25% of deaths were HCV-related, 12% of deaths were due to accident, overdose or suicide, and 8% were due to non-AIDS non-HCV related cancer. Among IV drug users, improvement in vital prognosis requires to improve management of HCV infection and to take into account socio-economic conditions and other addictive behaviours like alcohol consumption and smoking. DA - 2002/11// PY - 2002 DP - NCBI PubMed VL - 153 IS - 7 Suppl SP - 2S4 EP - 10 J2 - Ann Med Interne (Paris) LA - fre SN - 0003-410X KW - Adult KW - Cohort Studies KW - Female KW - France KW - HIV Infections KW - Humans KW - Male KW - Middle Aged KW - Substance-Related Disorders ER -